https://www.polarmicrobes.org/a-tale-of-two-studies-big-data-and-a-cautionary-analogy/ Marine Microbial Ecology Tue, 18 Oct 2016 01:06:03 +0000 hourly 1 https://wordpress.org/?v=6.9 https://www.polarmicrobes.org/a-tale-of-two-studies-big-data-and-a-cautionary-analogy/#comment-276 Tue, 21 Jul 2015 20:14:31 +0000 http://www.polarmicrobes.org/?p=1162#comment-276 The astute observer will note that the real problem with the experiment as described above is pseudoreplication. We treated every protein as an independent sample, but as they are grouped among 38 genomes we probably can’t do this. Mixed effects models are one way to get around this, but they are a little underpowered for this dataset (i.e. we don’t have enough genomes in our comparison).

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